Tandem Rh (II) and Chiral Squaramide Relay Catalysis: Enantioselective Synthesis of Dihydro-β-carbolines via Insertion to C–H Bond and Aza-Michael Reaction.

DOI Number:

10.1021/acs.orglett.9b00652

Reaction Category:

Educt:

(E)-3-(1-methylindolin-2-yl)-1-phenylprop-2-en-1-one, 4-phenyl-1-(phenylsulfonyl)-1H-1,2,3-triazole

Product:

2-((1R)-9-methyl-4-phenyl-2-(phenylsulfonyl)-2,4a,9,9a-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-1-phenylethan-1-one

Catalyst:

rhodium(II) acetate, 3-[(8α,9S)-cinchonan-9-ylamino]-4-[(phenylmethyl)amino]-3-Cyclobutene-1,2-dione

Cas No:

1228363-03-8

Cas No:

485-71-2