Organocatalytic Enantioselective 1,6-aza-Michael Addition of Isoxazolin-5-ones to p-Quinone Methides.

DOI Number:

10.1002/ejoc.201901907

Reaction Category:

RXNO ID:

RXNO_0000009

Educt:

3-methylisoxazol-5(4H)-one, 2,6-di-tert-butyl-4-(2-chlorobenzylidene)cyclohexa-2,5-dien-1-one

Product:

(R)-2-((2-chlorophenyl)(3,5-di-tert-butyl-4-hydroxyphenyl)methyl)-3-methylisoxazol-5(2H)-one

Catalyst:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′- [(8α,9S)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-16-7

Associated Product from Buchler GmbH:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-16-7