Organocatalytic asymmetric N-sulfonyl amide CN bond activation to access axially chiral biaryl amino acids.

DOI Number:

10.1038/s41467-020-14799-8
Link to literature

Reaction Category:

Atropisomer synthesis

Educt:

1,3-dimethyl-5-tosylbenzo[k]phenanthridin-6(5H)-one, phenylmethanol

Product:

biaryl amino acids

Catalyst:

3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1256245-84-7

Associated Product from Buchler GmbH:

3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1256245-84-7