Asymmetric Construction of All‐Carbon Quaternary Stereocenters via Organocatalytic α‐Hydroxymethylation of Malonic Diesters Using Aqueous Formaldehyde.
DOI Number:
10.1002/ajoc.202200101
Reaction Category:
Educt:
1-(tert-butyl) 3-methyl 2-substituted malonate, formaldehyde
Product:
1-(tert-butyl) 3-methyl 2-substituted-2-(hydroxymethyl)malonate
Catalyst:
3-cyclobutene-1,2-dione, 3,4-bis[[3,5-bis(trifluoromethyl)phenyl]amino], Cinchonidine Base
Cas No:
485-71-2
Associated Product from Buchler GmbH:
Cinchonidine Base
Cas No:
485-71-2