Light-mediated catalytic enantioselective difluoroalkylation of β-ketoesters via phase-transfer catalysis.

DOI Number:

10.1039/D4QO00390J
Link to literature

Reaction Category:

Alkylation | Alkylation

MOP ID:

MOP_0000369

Educt:

methyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylate, ethyl 2,2-difluoro-2-iodoacetate

Product:

methyl (R)-2-(2-ethoxy-1,1-difluoro-2-oxoethyl)-1-oxo-2,3-dihydro-1H-indene-2-carboxylate

Catalyst:

1-[2-([1,1′-biphenyl]-2-ylamino)-2-oxoethyl]- 9-hydroxy-(8α,9R)-Cinchonanium bromide

Cas No:

2380293-72-9

Associated Product from Buchler GmbH:

Cinchonidine Base

Cas No:

485-71-2