Highly enantioselective construction of 3-hydroxy oxindoles through a decarboxylative aldol addition of trifluoromethyl α-fluorinated gem-diols to N-benzyl isatins.

DOI Number:

10.1002/anie.201301443
Link to literature

Reaction Category:

Aldol | Aldol

RXNO ID:

RXNO_0000016

Educt:

N-benzyl isatins, rifluoromethyl α-fluorinated gem-diols

Product:

3-hydroxy oxindoles

Catalyst:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-16-7

Associated Product from Buchler GmbH:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-16-7