Umpolung Chemo-and Regioselective Cascade Addition of Diethylzinc to α-Diketones Followed by Intramolecular Michael Reaction: Stereoselective Synthesis of Highly Substituted 1-Indanones.

DOI Number:

10.1021/acs.orglett.2c02539

Reaction Category:

RXNO ID:

RXNO_0000009

Educt:

(E)-1-(2-(3-oxo-3-phenylprop-1-en-1-yl)phenyl)-2-phenylethane-1,2-dione, diethylzinc

Product:

(2R,3R)-2-ethoxy-3-(2-oxo-2-phenylethyl)-2-phenyl-2,3-dihydro-1H-inden-1-one

Catalyst:

Cinchonidine Base

Cas No:

485-71-2

Cas No:

485-71-2