Quinine Hydrochloride Dihydrate

Quinine Hydrochloride Dihydrate (CAS-No. 6119-47-7) is an API and a beverage ingredient produced by Buchler GmbH (cGMP and IFS certified).

Application

The most well-known Cinchona Alkaloid compound is Quinine, obtained by extraction from Cinchona bark. It is used as a natural flavouring mainly in beverages like bitter lemon and tonic water being often used as a mixer with gin or vodka. Quinine is responsible for the unique bitter taste in drinks. A limit concentration of 100 mg/kg for soft drinks and 250 mg/kg for spirit drinks, expressed as Quinine Base, is defined in the Regulation (EC) No 110/2008. In general tonic water contains an average of about 60 milligrams of Quinine Base per litre. Apart from Quinine Hydrochloride Dihydrate, Quinine Base and Quinine Sulfate are the preferred flavouring compounds.

Physical properties

Quinine Hydrochloride (CAS-No.: 6119-47-7) is a white or almost white, crystalline powder or it consists of fine, colourless needles, being  soluble in water, ethanol, CHCl₃ and methanol. The melting point is 123°C. This compound is not hygroscopic and contains 6.0-10.0 % water. It could be stored at ambient conditions in well-closed, light-resistant containers. Buchler is the leading manufacturer of Quinine Hydrochloride.

Synonyms

Chinin Hydrochlorid Dihydrat, Cinchonan-9-ol, 6′-methoxy-, monohydrochloride, dihydrate, (8α,9R)- (9CI), (R)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol hydrochloride dihydrate.