Michael Addition, tert-butyl (E)-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-2-enoyl)-2-methylbenzoate, 2-hydroxy-2-methylpropanenitrile, tert-butyl (R)-4-(3-cyano-3-(3,5-dichlorophenyl)-4,4,4-trifluorobutanoyl)-2-methylbenzoate, (8α,9R)-1-(9-anthracenylmethyl)-9-hydroxy-6′-methoxy-cinchonanium chloride, Quinine Derivative by werner@buchler-gmbh.com | Mar 18, 2026
Epoxidation, tert-butyldimethyl(((8S,13S,14S,17S)-13-methyl-17-(prop-1-yn-1-yl)-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2′-[1,3]dioxolan]-17-yl)oxy)silane, hydrogen peroxide, tert-butyldimethyl(((5’R,8’S,10’R,13’S,14’S,17’S)-13′-methyl-17′-(prop-1-yn-1-yl)-1′,2′,7′,8′,12′,13′,14′,15′,16′,17′-decahydro-4’H,6’H-spiro[[1,3]dioxolane-2,3′-[5,10]epoxycyclopenta[a]phenanthren]-17′-yl)oxy)silane, (8α,9R)-9-hydroxy-6′-methoxy-1-(phenylmethyl)-cinchonanium bromide, Quinine Derivative by werner@buchler-gmbh.com | Mar 18, 2026
Oxa-Michael, (E)-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-2-enoyl)-2-methylbenzamide, hydroxylamine, isoxazoline compounds, (8α,9R)-1-(9-acridinylmethyl)-9-hydroxy-6′-methoxy-cinchonanium bromide, Quinine Derivative by werner@buchler-gmbh.com | Mar 18, 2026
Desymmetrization, hexahydroisobenzofuran-1,3-dione, 2-(methoxycarbonyl)cyclohexane-1-carboxylic acid, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine Derivative by werner@buchler-gmbh.com | Jul 30, 2025
Spirocyclization, Methyl 1-tert-butyl-2-hydroxypyrrolo[2,3-b]pyridine-3-carboxylate, (2-(Chloromethyl)-4-(dibenzylamino)phenyl)methanol hydrochloride, (2R)-5-[Bis(phenylmethyl)amino]-1′-(1,1-dimethylethyl)-1,3-dihydrospiro[2H-indene-2,3′-[3H]pyrrolo[2,3-b]pyridin]-2′(1′H)-on, 1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-hydroxy-(9R)-cinchonanium bromide, Cinchonidine Derivative by Anna-Lena Hartmann | Jun 27, 2025
