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Spirocyclization (Sulfa-Michael Aldol-Cascade), 1,4-dithiane-2,5-diol, N/C-substituted-(E)-[3,3′-biindolinylidene]-2,2′-dione, N/C-substituted-(3S,3’R,4’R)-4′-hydroxy-4′,5′-dihydrodispiro[indoline-3,2′-thiophene-3′,3”-indoline]-2,2”-dione, Quinine Base

by werner@buchler-gmbh.com | Feb 21, 2023

[4+2] Cycloaddition, 5-phenylpenta-3,4-dien-2-one, (E)-4-benzylidene-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, (S)-1-(6-benzyl-3-methyl-1,4-diphenyl-1,4-dihydropyrano[2,3-c]pyrazol-5-yl)ethan-1-one, Quinine Base

by werner@buchler-gmbh.com | Feb 21, 2023

Desymmetrization, 4-phenyldihydro-2H-pyran-2,6(3H)-dione, azidotrimethylsilane, hydrochloric acid, intermediate: (R)-5-azido-5-oxo-3-phenylpentanoic acid, (R)-4-phenylpyrrolidin-2-one, Quinine Derivative

by Anna-Lena Hartmann | Nov 10, 2022

Isoxazoline cyclization, 4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobutanoyl)-N-(1,1-dioxidothietan-3-yl)-2-methylbenzamide, hydroxylamine, 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1-dioxidothietan-3-yl)-2-methylbenzamide, (8α,9R)-9-hydroxy-6′-methoxy-1-[(2,3,4,5,6-pentafluorophenyl)methyl]-Cinchonanium chloride, Quinine Derivative

by Anna-Lena Hartmann | Sep 26, 2022

Aza-Henry (Nitro-Mannich), ethyl (E)-2-((4-methoxyphenyl)imino)acetate, tert-butyl 2-nitropropanoate, 1-(tert-butyl) 4-ethyl (2S,3R)-3-((4-methoxyphenyl)amino)-2-methyl-2-nitrosuccinate, Quinine Base

by Anna-Lena Hartmann | Sep 22, 2022

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