Any hydrocarbon or heterocycle with 4n+2 electrons in a fully conjugated cyclic π system is considered to be an...
Buchler Glossary
Pictet–Spengler reaction is a chemical reaction in which a β-arylethylamine undergoes condensation with an aldehyde or ketone followed by ring closure. This kind of reaction is a century old technique for the construction of aza-cycles. The Pictet-Spengler reaction is a straightforward approach toward the construction of nitrogen containing heterocycles through C-C bond formation. This Mannich-type cyclization involves an intramolecular aromatic electrophilic substitution mechanism of electron-rich aromatic or heteroaromatic rings to an imine or iminium ion. In order to obtain chiral aza-cycles Cinchona alkaloid catalysts can be used.
Further Articles:
Asymmetric Aldol Reaction
The aldol reaction is one of the most important and effective methodologies for the straightforward construction of...
Asymmetric Alkylation
Alkylation is the introduction of an alkyl group into an organic compound by substitution or addition. The alkyl group...
Asymmetric Amination
Amination is the process by which an amine group is introduced into an organic molecule. This type of reaction is...
Asymmetric Dihydroxylation
Asymmetric Dihydroxylation of olefins is of high synthetic value because it introduces two vicinal hydroxy groups,...