Any hydrocarbon or heterocycle with 4n+2 electrons in a fully conjugated cyclic π system is considered to be an...
Buchler Glossary
Dearomatization
A dearomatization reaction is an organic reaction which involves arenes as reactants and in which the reaction products have permanently lost their aromaticity. Dearomatization reactions provide rapid access to structurally complex three-dimensional molecules from simple aromatic compounds.
Please find further examples of Dearomatizations promoted by Cinchona Alkaloids in our Buchler Chiral Catalyst Search.
Example from literature
Organocatalytic Asymmetric One-Step Desymmetrizing Dearomatization Reaction of Indoles: Development and Bioactivity Evaluation. (Peng er al.; Angew. Chem. Int. Ed. 2019, 58, 216–220.)
Further Articles:
Asymmetric Aldol Reaction
The aldol reaction is one of the most important and effective methodologies for the straightforward construction of...
Asymmetric Alkylation
Alkylation is the introduction of an alkyl group into an organic compound by substitution or addition. The alkyl group...
Asymmetric Amination
Amination is the process by which an amine group is introduced into an organic molecule. This type of reaction is...
Asymmetric Dihydroxylation
Asymmetric Dihydroxylation of olefins is of high synthetic value because it introduces two vicinal hydroxy groups,...