Alkynylation is an addition reaction in organic synthesis where a terminal alkyne adds to a carbonyl group to form an α-alkynyl alcohol. When the acetylide is formed from acetylene, the reaction gives an α-ethynyl alcohol. This process is often referred to as ethynylation.

Please find several examples of Alkynylation reactions promoted by Cinchona Alkaloids in our Buchler Chiral Catalyst Search.

Example from literature

Practical Asymmetric Conjugate Alkynylation of Meldrum’s Acid-Derived Acceptors: Access to Chiral β-Alkynyl Acids. (Cui et al.; J. Am. Chem. Soc. 2010, 132, 2, 436-437.)