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Atropisomer Synthesis, terminal alkynes, tert-butyl 2-bromo-2-methylpropanoate, atropisomer, 2-[Bis[2-(1-methylethyl)phenyl]phosphino]-N-[(8α,9S)-6′-methoxycinchonan-9-yl]benzamide, Quinine Derivative

Atropisomer synthesis

Desymmetrization, fittig’s lactones, methanol-d, 3-keto-5-methoxy-5-oxopentanoic acid, 3-[(di-1-naphthalenylmethyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine Derivative

Desymmetrization

Cascade reaction, o-quinone methides, β-keto acylpyrazoles, trans-3,4-dihydrocoumarins, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine Derivative

Cascade reaction

Lactonization, substituted phenols, substituted oxazol-5(4H)-ones, chiral dihydrocoumarins, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine Derivative

Lactonization

Spirocyclization, substituted 4-(2-hydroxybenzylidene)cyclohexa-2,5-dien-1-one, substituted 1-oxo-1,2,3,4-tetrahydronaphthalene-2-carbaldehyde, spiro-3,4-dihydrocoumarins, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine Derivative

Spirocyclization

Spirocyclization, 3-alkylidene oxindoles, isatins, spirooxindole dihydropyranones, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine Derivative

Aldol, Cascade reaction, Spirocyclization, Vinylogous Aldol

Spirocyclization, N-alkoxy-4-oxo-acrylamides, isatin-derived ketimines, spirooxindole-imidazolidinones, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine Derivative

[3+2]-Cycloaddition, Cycloaddition, Spirocyclization

Cyclization, substituted 5-methylenethiazol-4(5H)-one, 2,4,4,4-tetrafluoro-3,3-dihydroxy-1-phenylbutan-1-one, pyran derivatives, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine Derivative

Cyclization, Cyclization, Further Cyclizations

Atropisomer Synthesis, substituted 1-ethynylnaphthalen-2-ol, tetrasubsituted phosphinothioic thioanhydride, phosphorodithiolated styrenes, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine Derivative

Atropisomer synthesis

Michael Addition, diethyl 2-((2,2,2-trifluoroethyl)imino)malonate, nitroalkenes, 4-substituted diethyl (3R,5R)-3-nitro-5-(trifluoromethyl)pyrrolidine-2,2-dicarboxylate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine Derivative

Cascade reaction, Michael, Michael Addition

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