Highly enantioselective organocatalyzed vinylogous Michael-type reaction for the construction of trifluoromethylated all-carbon quaternary stereocenters.

DOI Number:

10.1021/ol500157b

Reaction Category:

Educt:

tert-butyl 2-oxo-3-(propan-2-ylidene)indoline-1-carboxylate, (E)-(3,3,3-trifluoro-1-nitroprop-1-en-2-yl)benzene

Product:

tert-butyl (R,Z)-2-oxo-3-(5,5,5-trifluoro-4-(nitromethyl)-4-phenylpentan-2-ylidene)indoline-1-carboxylate

Catalyst:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-16-7

Cas No:

130-95-0