Ring-Strain-Enabled Catalytic Asymmetric Umpolung C–O Bond-Forming Reactions of 1, 2-Oxazetidines for the Synthesis of Functionalized Chiral Ethers.

DOI Number:

10.1021/acs.orglett.0c01916
Link to literature

Reaction Category:

Further reactions | Umpolung

Educt:

substituted tert-butyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylate, 3,4-disubstituted-2-((4-nitrophenyl)sulfonyl)-1,2-oxazetidine

Product:

substituted tert-butyl (2S)-2-(1,2-disubstituted-2-((4-nitrophenyl)sulfonamido)ethoxy)-1-oxo-2,3-dihydro-1H-indene-2-carboxylate

Catalyst:

(9S)-1-[[4,4′′-bis(1,1-dimethylethyl)[1,1′:4′,1′′-terphenyl]-2′-yl]methyl]-9-(2,2-dimethyl-1-oxopropoxy)-cinchonanium bromide

Cas No:

2473830-67-8

Associated Product from Buchler GmbH:

Cinchonine Base

Cas No:

118-10-5