In situ generation of electrophilic trifluoromethylthio reagents for enantioselective trifluoromethylthiolation of oxindoles.

DOI Number:

10.1021/ol5006888
Link to literature

Reaction Category:

Trifluoro-methylthiolation

Educt:

3-substituted oxindoles, [(trifluoromethyl)thio]-silver

Product:

(S)-5-chloro-3-(4-chlorophenyl)-3-((trifluoromethyl)thio)indolin-2-one

Catalyst:

1,3,5-Trichloroisocyanuric acid, (9S,9′′S)-9,9′′-[(2,5-diphenyl-4,6-pyrimidinediyl)bis(oxy)]bis[10,11-dihydro-6′-methoxy-cinchonan]

Cas No:

149725-81-5

Associated Product from Buchler GmbH:

Dihydroquinidine Base

Cas No:

1435-55-8