Cinchona alkaloids/TMAF combination-catalyzed nucleophilic enantioselective trifluoromethylation of aryl ketones.

DOI Number:

10.1021/ol701791r

Reaction Category:

Educt:

aryl keteones, trimethyl(trifluoromethyl)silane

Product:

trifluoromethyl-substituted aryl alcohols

Catalyst:

(1S,1'S,2R,2'R,4S,4'S,5R,5'R)-1,1'-(1,3-phenylenebis(methylene))bis(2-((S)-hydroxy(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium) bromide, tetramethylammonium fluoride

Cas No:

479070-35-4

Cas No:

118-10-5