Cinchona alkaloids/TMAF combination-catalyzed nucleophilic enantioselective trifluoromethylation of aryl ketones.
DOI Number:
10.1021/ol701791r
Reaction Category:
MOP ID:
MOP_0000553
Educt:
aryl keteones, trimethyl(trifluoromethyl)silane
Product:
trifluoromethyl-substituted aryl alcohols
Catalyst:
(1S,1'S,2R,2'R,4S,4'S,5R,5'R)-1,1'-(1,3-phenylenebis(methylene))bis(2-((S)-hydroxy(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium) bromide, tetramethylammonium fluoride
Cas No:
479070-35-4
Associated Product from Buchler GmbH:
Cinchonine Base
Cas No:
118-10-5