The synthesis of chiral β-naphthyl-β-sulfanyl ketones via enantioselective sulfa-Michael reaction in the presence of a bifunctional cinchona/sulfonamide organocatalyst.

DOI Number:

10.3762/bjoc.17.43

Reaction Category:

RXNO ID:

RXNO_0000009

Educt:

naphthalene-1-thiol, (E)-1-phenyl-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

Product:

(S)-3-(naphthalen-1-ylthio)-1-phenyl-3-(3,4,5-trimethoxyphenyl)propan-1-one

Catalyst:

N-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)-2,4,6-trimethyl-3-nitrobenzenesulfonamide

Cas No:

not found

Cas No:

130-95-0