Highly enantioselective organocatalytic Strecker reaction of cyclic N-acyltrifluoromethylketimines: Synthesis of anti-HIV drug DPC 083.

DOI Number:

10.1039/C2CC36307K

Reaction Category:

Educt:

6-chloro-1-(4-methoxybenzyl)-4-(trifluoromethyl)quinazolin-2(1H)-one, trimethylsilanecarbonitrile

Product:

(R)-6-chloro-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazoline-4-carbonitrile

Catalyst:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′- [(8α,9S)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-16-7

Cas No:

130-95-0