Highly enantioselective organocatalytic Strecker reaction of cyclic N-acyltrifluoromethylketimines: Synthesis of anti-HIV drug DPC 083.
DOI Number:
10.1039/C2CC36307K
Reaction Category:
RXNO ID:
RXNO_0000207
Educt:
6-chloro-1-(4-methoxybenzyl)-4-(trifluoromethyl)quinazolin-2(1H)-one, trimethylsilanecarbonitrile
Product:
(R)-6-chloro-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazoline-4-carbonitrile
Catalyst:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′- [(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0