Efficient enantioselective synthesis of CF2H-containing dispiro[benzo[b]thiophene-oxindole-pyrrolidine]s via organocatalytic cycloaddition.

DOI Number:

10.1039/D1QO01392K
Link to literature

Reaction Category:

Spirocyclization

Educt:

substituted (Z)-2-((2,2-difluoroethyl)imino)benzo[b]thiophen-3(2H)-one, substituted 3-methyleneindolin-2-one

Product:

CF2H-containing dispiro[benzo[b]thiophene-oxindole-pyrrolidine]s

Catalyst:

3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1256245-84-7

Associated Product from Buchler GmbH:

Quinine Base

Cas No:

130-95-0