An organocatalytic Michael-aldol cascade: formal [3+2] annulation to construct enantioenriched spirocyclic oxindole derivatives.
DOI Number:
10.1039/C2CC30931A
Reaction Category:
RXNO ID:
RXNO_0000016
Educt:
substituted ethyl (E)-2-(1-methyl-2-oxoindolin-3-ylidene)acetate, 1,4-dithiane-2,5-diol
Product:
substituted ethyl (2'S,3R,4'R)-4'-hydroxy-1-methyl-2-oxo-4',5'-dihydro-2'H-spiro[indoline-3,3'-thiophene]-2'-carboxylate
Catalyst:
3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[(9R)-cinchonan-9-ylamino]-3- cyclobutene-1,2-dione
Cas No:
1256245-82-5
Associated Product from Buchler GmbH:
Cinchonine Base
Cas No:
118-10-5