Asymmetric construction of bispiro [oxindole-pyrrolidine-rhodanine]s via squaramide-catalyzed domino Michael/Mannich [3+2] cycloaddition of rhodanine derivatives with N-(2,2,2-trifluoroethyl) isatin ketimines.
DOI Number:
10.1021/acs.joc.8b01245
Reaction Category:
Educt:
rhodanine derivatives, N-(2,2,2-trifluoroethyl) isatin ketimines
Product:
bispiro [oxindole-pyrrolidine-rhodanine]s
Catalyst:
3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione
Cas No:
1256245-85-8
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0