Asymmetric synthesis of tetrahydroisoquinoline-fused spirooxindoles as Ras-GTP inhibitors that inhibit colon adenocarcinoma cell proliferation and invasion.

DOI Number:

10.1039/C8CC04732D

Reaction Category:

Educt:

N/C-substituted tert-butyl (E)-(2-oxoindolin-3-ylidene)carbamate, 2-methyl-3,5-dinitrobenzaldehyde

Product:

N/C-substituted tert-butyl (1'R,3R)-1'-hydroxy-5',7'-dinitro-2-oxo-1',4'-dihydro-2'H-spiro[indoline-3,3'-isoquinoline]-2'-carboxylate

Catalyst:

Cinchonine Base

Cas No:

118-10-5

Cas No:

118-10-5