Recyclable organocatalyst‐promoted one‐pot asymmetric synthesis of spirooxindoles bearing multiple stereogenic centers.

DOI Number:

10.1002/adsc.201500748
Link to literature

Reaction Category:

Spirocyclization

Educt:

ethyl (E)-2-(1-methyl-2-oxoindolin-3-ylidene)acetate, diethyl malonate, 4-fluorobenzaldehyde, ammonium acetate

Product:

diethyl (2'R,3R,4'R,5'R)-2'-(4-fluorophenyl)-1-methyl-2,6'-dioxospiro[indoline-3,3'-piperidine]-4',5'-dicarboxylate

Catalyst:

N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea

Cas No:

1456767-79-5

Associated Product from Buchler GmbH:

Dihydroquinine Base

Cas No:

522-66-7