Asymmetric Synthesis of Spiropyrazolones by Sequential Organo- and Silver Catalysis.

DOI Number:

10.1002/anie.201510602
Link to literature

Reaction Category:

Spirocyclization

Educt:

(E)-1-ethynyl-2-(2-nitrovinyl)benzene, 5-methyl-2-(p-tolyl)-2,4-dihydro-3H-pyrazol-3-one

Product:

(2R,3R)-3'-methyl-1-methylene-3-(nitromethyl)-1'-(p-tolyl)-1,3-dihydrospiro[indene-2,4'-pyrazol]-5'(1'H)-one

Catalyst:

3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1204591-53-6

Associated Product from Buchler GmbH:

Dihydroquinine Base

Cas No:

522-66-7