The Regiocontrollable Enantioselective Synthesis of Chiral Trifluoromethyl-Containing Spiro-Pyrrolidine-Pyrazolone Compounds via Amino-Regulated 1,3-Proton Migration Reaction.

DOI Number:

10.1021/acs.joc.1c01705

Reaction Category:

RXNO ID:

RXNO_0000018

Educt:

diethyl 2-((2,2,2-trifluoroethyl)imino)malonate, substituted (E)-4-benzylidene-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one

Product:

trifluoromethyl-containing spiro-pyrrolidine-pyrazolone compounds

Catalyst:

3-[[(9R)-6′-Methoxycinchonan-9-yl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione

Cas No:

1256245-80-3

Cas No:

56-54-2