Asymmetric synthesis of spirooxindole-fused spirothiazolones via squaramide-catalysed reaction of 3-chlorooxindoles with 5-alkenyl thiazolones.

DOI Number:

10.1039/c9ob00998a
Link to literature

Reaction Category:

Alkylation | Alkylation | Cascade reaction | Cyclopropanation | Spirocyclization

MOP ID:

MOP_0000369

Educt:

(Z)-5-(2-methylbenzylidene)-2-phenylthiazol-4(5H)-one, 3-chloroindolin-2-one

Product:

(2'S,3R,3'S)-2''-phenyl-3'-(o-tolyl)-4''H-dispiro[indoline-3,1'-cyclopropane-2',5''-thiazole]-2,4''-dione

Catalyst:

3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1352957-59-5

Associated Product from Buchler GmbH:

Dihydroquinine Base

Cas No:

522-66-7