Organocatalytic asymmetric oxy-Michael addition to a γ-hydroxy-α, β-unsaturated thioester via hemiacetal intermediates.

DOI Number:

10.1039/C2CC31602A
Link to literature

Reaction Category:

Cyclization | Cyclization | Further Cyclizations | Michael Addition | Oxa-Michael Addition

MOP ID:

MOP_0000561

Educt:

S-(2,6-dimethylphenyl) (E)-4-hydroxybut-2-enethioate, pivalaldehyde

Product:

S-(2,6-dimethylphenyl) 2-((2S,4S)-2-(tert-butyl)-1,3-dioxolan-4-yl)ethanethioate

Catalyst:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′- methoxycinchonan-9-yl]thiourea

Cas No:

852913-25-8

Associated Product from Buchler GmbH:

Quinidine Base

Cas No:

56-54-2