A new synthetic route for the preparation of pregabalin.

DOI Number:

10.1080/00397911.2021.1919710
Link to literature

Reaction Category:

Michael | Michael Addition

Educt:

(R,E)-3-(5-methylhex-2-enoyl)-4-phenyloxazolidin-2-one

Product:

(R)-3-((S)-5-methyl-3-(nitromethyl)hexanoyl)-4-phenyloxazolidin-2-one

Catalyst:

(9S)-9-hydroxy-1-(phenylmethyl)-cinchonanium chloride

Cas No:

69221-14-3

Associated Product from Buchler GmbH:

Cinchonine Base

Cas No:

118-10-5