Partially saturated fluorinated heterocycles: Diastereo-and enantioselective synthesis of β-trifluoromethyl-pyrroline carboxylates.

DOI Number:

10.1039/C2CC18052A
Link to literature

Reaction Category:

Cyclization | Cyclization | Michael | Michael Addition

MOP ID:

MOP_0000561

Educt:

(E)-4,4,4-trifluoro-1-(4-methoxyphenyl)but-2-en-1-one, (3s,5s,7s)-adamantan-1-yl 2-((diphenylmethylene)amino)acetate

Product:

(3S,5S,7S)-adamantan-1-yl (2R,3R)-5-(4-methoxyphenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrole-2-carboxylate

Catalyst:

1-[[3,5-bis(1,1-dimethylethyl)phenyl]methyl]-9-hydroxy-(9S)-Cinchonanium bromide

Cas No:

1190864-60-8

Associated Product from Buchler GmbH:

Cinchonine Base

Cas No:

118-10-5