Asymmetric Direct Vinylogous Conjugate Addition of Unsaturated-Butyrolactam to Acyl Acrylonitriles using Organocatalysts.

DOI Number:

10.1002/ajoc.202300082
Link to literature

Reaction Category:

Michael | Michael Addition

RXNO ID:

RXNO_0000009

Educt:

(E)-4-(furan-2-yl)-4-oxobut-2-enenitrile, tert-butyl 2-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

Product:

tert-butyl (S)-2-((S)-1-cyano-3-(furan-2-yl)-3-oxopropyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

Catalyst:

N-[3,5-bis(trifluoromethyl)phenyl]-N′- [(8α,9S)-10,11-dihydro-6′-methoxy- cinchonan-9-yl]-Thiourea

Cas No:

852913-19-0

Associated Product from Buchler GmbH:

Dihydroquinine Base

Cas No:

522-66-7