Development and scale-up of an organocatalytic enantioselective process to manufacture (S)-pregabalin.
DOI Number:
10.1021/acs.oprd.5b00160
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
(E)-3-methyl-5-(4-methylpent-1-en-1-yl)-4-nitroisoxazole, nitromethane
Product:
(S)-3-methyl-5-(4-methyl-2-(nitromethyl)pentyl)-4-nitroisoxazole
Catalyst:
(9S)-1-[[3,5-bis(1,1-dimethylethyl)phenyl]methyl]-9-hydroxy-6′-methoxy-cinchonanium bromide
Cas No:
1245905-96-7
Associated Product from Buchler GmbH:
Quinidine Base
Cas No:
56-54-2