Efficient and highly enantioselective construction of trifluoromethylated quaternary stereogenic centers via high-pressure mediated organocatalytic conjugate addition of nitromethane to β,β-disubstituted enones.
DOI Number:
10.1021/ol502941d
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
beta,beta-disubstituted enones, nitromethane
Product:
substituted 4,4,4-trifluoro-3-(nitromethyl)butanoyl
Catalyst:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-25-8
Associated Product from Buchler GmbH:
Quinidine Base
Cas No:
56-54-2