Base-catalyzed asymmetric α-functionalization of 2-(cyanomethyl) azaarene N-oxides leading to quaternary stereocenters.
DOI Number:
10.1021/jacs.5b13385
Reaction Category:
Educt:
2-(cyano(phenyl)methyl)pyridine-1-oxide, 4-hydroxy-4-methylpent-1-en-3-one
Product:
(R)-2-(1-cyano-5-hydroxy-5-methyl-4-oxo-1-phenylhexyl)pyridine-1-oxide
Catalyst:
4-[[(dimethylphenylsilyl)methyl]amino]-3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione
Cas No:
1883767-85-8
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0