Base-catalyzed asymmetric α-functionalization of 2-(cyanomethyl) azaarene N-oxides leading to quaternary stereocenters.

DOI Number:

10.1021/jacs.5b13385

Reaction Category:

RXNO ID:

RXNO_0000009

Educt:

2-(cyano(phenyl)methyl)pyridine-1-oxide, 4-hydroxy-4-methylpent-1-en-3-one

Product:

(R)-2-(1-cyano-5-hydroxy-5-methyl-4-oxo-1-phenylhexyl)pyridine-1-oxide

Catalyst:

4-[[(dimethylphenylsilyl)methyl]amino]-3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione

Cas No:

1883767-85-8

Cas No:

130-95-0