Direct Catalytic Asymmetric Mannich Reaction with Dithiomalonates as Excellent Mannich Donors: Organocatalytic Synthesis of (R)‐Sitagliptin.
DOI Number:
10.1002/anie.201605167
Reaction Category:
RXNO ID:
RXNO_0000032
Educt:
tert-butyl (1-(phenylsulfonyl)-2-(2,4,5-trifluorophenyl)ethyl)carbamate, dithiomalonates
Product:
S,S-dibenzyl (R)-2-(1-((tert-butoxycarbonyl)amino)-2-(2,4,5-trifluorophenyl)ethyl)propanebis(thioate)
Catalyst:
3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-(((R)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione
Cas No:
1073917-09-5
Associated Product from Buchler GmbH:
Quinidine Base
Cas No:
56-54-2