Direct Catalytic Asymmetric Mannich Reaction with Dithiomalonates as Excellent Mannich Donors: Organocatalytic Synthesis of (R)‐Sitagliptin.
DOI Number:
10.1002/anie.201605167
Reaction Category:
RXNO ID:
RXNO_0000032
Educt:
tert-butyl (1-(phenylsulfonyl)-2-(2,4,5-trifluorophenyl)ethyl)carbamate, dithiomalonates
Product:
S,S-dibenzyl (R)-2-(1-((tert-butoxycarbonyl)amino)-2-(2,4,5-trifluorophenyl)ethyl)propanebis(thioate)
Catalyst:
3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione
Cas No:
1362169-08-1
Associated Product from Buchler GmbH:
Quinidine Base
Cas No:
56-54-2