Direct enantio-and diastereoselective Mannich reactions of malonate and β-keto esters with N-Boc and N-Cbz aldimines catalysed by a bifunctional cinchonine derivative.

DOI Number:

10.1039/B515725K
Link to literature

Reaction Category:

Mannich | Mannich

RXNO ID:

RXNO_0000032

Educt:

substituted methylenecarbamate, dimethyl malonate

Product:

substituted dimethyl (S)-2-(((carbonyl)amino)methyl)malonate

Catalyst:

N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-thiourea

Cas No:

851477-19-5

Associated Product from Buchler GmbH:

Cinchonine Base

Cas No:

118-10-5