Modified asymmetric Strecker reaction of aldehyde with secondary amine: A protocol for the synthesis of S-clopidogrel (an antiplatelet agent).
DOI Number:
10.1021/jo300642z
Reaction Category:
RXNO ID:
RXNO_0000032
Educt:
2-chlorobenzaldehyde, 4,5,6,7-tetrahydrothieno[3,2-c]pyridine, trimethylsilanecarbonitrile
Product:
(S)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile
Catalyst:
Dihydroquinine Base
Cas No:
522-66-7
Associated Product from Buchler GmbH:
Dihydroquinine Base
Cas No:
522-66-7