Process for the preparation of enantiomerically enriched isoxazoline compounds - crystalline toluene solvate of (s)-afoxolaner.
DOI Number:
Patent: WO2017176948A1
Reaction Category:
MOP ID:
MOP_0000561
Educt:
4-(3-(3-chloro-5-(trifluoromethyl)phenyl)-4,4,4-trifluorobut-2-enoyl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-1-naphthamide
Product:
(S)-4-(5-(3-chloro-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-1-naphthamide
Catalyst:
N-3,4,5-tris(benzyloxy)benzyl-quininium Bromide
Cas No:
2138407-50-6
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0