A New Class of Urea-Substituted Cinchona Alkaloids Promote Highly Enantioselective Nitroaldol reactions of Trifluoromethyl-ketones.

DOI Number:

10.1021/ol103089j

Reaction Category:

RXNO ID:

RXNO_0000086

Educt:

1,1,1-trifluoro-3-phenylpropan-2-one, nitromethane

Product:

(S)-1,1,1-trifluoro-2-nitro-3-phenylpropan-2-ol

Catalyst:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9R)-9-[[[[3,5-bis(trifluoromethyl)phenyl]amino]carbonyl]oxy]-10,11-dihydro-6′-methoxycinchonan-5′-yl]-urea

Cas No:

1269656-94-1

Cas No:

522-66-7