Asymmetric Synthesis of Both Mirror Images of 3′-Fluorothalidomide by Enantiodivergent Fluorination Using a Single, Cinchona Alkaloid.

DOI Number:

10.1021/ol102818g
Link to literature

Reaction Category:

Fluorination | Fluorination

MOP ID:

MOP_0000553

Educt:

tert-butyl 3-(1,3-dioxoisoindolin-2-yl)-2-oxopiperidine-1-carboxylate, N-fluoro-N-(phenylsulfonyl)benzenesulfonamide

Product:

tert-butyl (R)-3-(1,3-dioxoisoindolin-2-yl)-3-fluoro-2-oxopiperidine-1-carboxylate

Catalyst:

Dihydroquinine Base

Cas No:

522-66-7

Associated Product from Buchler GmbH:

Dihydroquinine Base

Cas No:

522-66-7