One-pot Fluorination and Organocatalytic Robinson Annulation for Asymmetric Synthesis of Mono- and Difluorinated Cyclohexenones.

DOI Number:

10.3390/molecules23092251

Reaction Category:

MOP ID:

MOP_0000553

Educt:

ethyl 3-oxobutanoate, 1-(chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium, (E)-3-(4-bromophenyl)-1-phenylprop-2-en-1-one

Product:

(1S,6S)-6-(4-bromophenyl)-1-fluoro-2-oxo-4-phenyl-3-Cyclohexene-1-carboxylic acid ethyl ester

Catalyst:

(8α,9S)-10,11-Dihydro-6′-methoxycinchonan-9-amine

Cas No:

852913-53-2

Cas No:

522-66-7