Fluorination, 3-(5-Chloro-2-methoxyphenyl)-1,3-dihydro-6-(trifluoromethyl)-2H-indol-2-one, 1-(chloromethyl)-4-fluoro-1,4-Diazoniabicyclo[2.2.2]octane tetrafluoroborate, (3S)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one (BMS-204352: MaxiPost, S-1), 1,4-bis[[(8α,9R)-10,11-dihydro-6′-methoxy- cinchonan-9-yl]oxy]-9,10-Anthracenedione, Dihydroquinine Derivative

Enantioselective Fluorination Mediated by N-Fluoroammonium Salts of Cinchona Alkaloids: First Enantioselective Synthesis of BMS-204352 (MaxiPost).

DOI Number:

10.1021/jo026792s

Link to literature

Reaction Category:

Fluorination | Fluorination

MOP ID:

MOP_0000553

Educt:

3-(5-Chloro-2-methoxyphenyl)-1,3-dihydro-6-(trifluoromethyl)-2H-indol-2-one, 1-(chloromethyl)-4-fluoro-1,4-Diazoniabicyclo[2.2.2]octane tetrafluoroborate

Product:

(3S)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one (BMS-204352: MaxiPost, S-1)

Catalyst:

1,4-bis[[(8α,9R)-10,11-dihydro-6′-methoxy- cinchonan-9-yl]oxy]-9,10-Anthracenedione

Cas No:

176097-24-8

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Associated Product from Buchler GmbH:

Dihydroquinine Base

Cas No:

522-66-7