Supported Bifunctional Chiral Thioureas as Catalysts in the Synthesis of 3‐Amino‐2‐Oxindoles through Enantioselective aza‐Friedel‐Crafts Reaction: Application in Continuous Flow Processes.
DOI Number:
10.1016/j.gresc.2022.07.004
Reaction Category:
RXNO ID:
RXNO_0000369
Educt:
tert-butyl (E)-(1-benzyl-2-oxo-7-(trifluoromethyl)indolin-3-ylidene)carbamate, naphthalen-1-ol
Product:
tert-butyl (R)-(1-benzyl-3-(1-hydroxynaphthalen-2-yl)-2-oxo-7-(trifluoromethyl)indolin-3-yl)carbamate
Catalyst:
supported N-[(8α,9S)-10,11-Dihydro-6′-methoxycinchonan-9-yl]thiourea
Cas No:
2418549-11-6
Associated Product from Buchler GmbH:
Dihydroquinine Base
Cas No:
522-66-7