Highly Diastereodivergent Synthesis of Tetrasubstituted Cyclohexanes Catalyzed by Modularly Designed Organocatalysts

DOI Number:

10.1002/anie.201404072
Link to literature

Reaction Category:

Cascade reaction | Cyclization

MOP ID:

MOP_0000561

Educt:

(E)-7-(4-methoxyphenyl)-7-oxohept-5-enal, (E)-5-(2-nitrovinyl)benzo[d][1,3]dioxole

Product:

(1S,2S,3R,4R)-2-(benzo[d][1,3]dioxol-5-yl)-4-(2-(4-methoxyphenyl)-2-oxoethyl)-3-nitrocyclohexane-1-carbaldehyde

Catalyst:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-25-8

Associated Product from Buchler GmbH:

Quinidine Base

Cas No:

56-54-2