Highly enantioselective synthesis of chiral cyclopropyl nucleosides via catalytic asymmetric intermolecular cyclopropanation.

DOI Number:

10.1021/acs.orglett.7b03110
Link to literature

Reaction Category:

Cyclopropanation

Educt:

ethyl 2-(6-chloro-9H-purin-9-yl)acrylate, tert-butyl 2-bromoacetate

Product:

2-(tert-butyl) 1-ethyl (1S,2R)-1-(6-chloro-9H-purin-9-yl)cyclopropane-1,2-dicarboxylate

Catalyst:

1,4-Bis(9-O-dihydroquinidinyl)anthraquinone

Cas No:

176298-44-5

Associated Product from Buchler GmbH:

1,4-Bis(9-O-dihydroquinidinyl)anthraquinone

Cas No:

176298-44-5