Enantioselective synthesis of substituted pyrans via amine-catalyzed Michael addition and subsequent enolization/cyclisation.

DOI Number:

10.1039/C2CC31445B

Reaction Category:

MOP ID:

MOP_0000565

Educt:

substituted 2-formylacrylonitrile, cyclohexanone

Product:

substituted (4aS,8aR)-8a-hydroxy-4a,5,6,7,8,8a-hexahydro-4H-chromene-3-carbonitrile

Catalyst:

(9R)-10,11-Dihydro-6′-methoxycinchonan-9-amine

Cas No:

522600-31-3

Cas No:

1435-55-8