Enantioselective Assembly of Fully Substituted α‐Amino Allenoates Through a Mannich Addition and Stepwise [3,3]‐σ Rearrangement Sequence.

DOI Number:

10.1002/advs.202409334
Link to literature

Reaction Category:

Cyclization | Cyclization | Further Cyclizations | Further reactions | Mannich | Mannich | Rearrangement

MOP ID:

MOP_0000561

Educt:

N-(prop-2-yn-1-yl)pivalamide, ethyl (Z)-2-((tert-butoxycarbonyl)imino)-4-phenylbut-3-ynoate

Product:

ethyl (S)-2-((tert-butoxycarbonyl)amino)-5-(2-(tert-butyl)oxazol-5-yl)-4-phenylpenta-2,3-dienoate

Catalyst:

3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-(phenylamino)-3-cyclobutene-1,2-dione

Cas No:

1528740-10-4

Associated Product from Buchler GmbH:

Quinine Base

Cas No:

130-95-0