Asymmetric Synthesis of Spiropyrazolone-Fused Dihydrofurannaphthoquinones Bearing Contiguous Stereocenters via a Michael Addition/Chlorination/Nucleophilic Substitution Sequence.

DOI Number:

10.1021/acs.joc.2c03013

Reaction Category:

Educt:

(Z)-4-benzylidene-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, 2-hydroxynaphthalene-1,4-dione

Product:

(2S,3R)-3'-methyl-1',3-diphenyl-3H-spiro[naphtho[2,3-b]furan-2,4'-pyrazole]-4,5',9(1'H)-trione

Catalyst:

3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1256245-84-7

Cas No:

130-95-0